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How Depo-Provera Betrayed the World's Women

Injectable contraceptives like Depo-Provera increase the risk of HIV transmission. A recent meta-analysis conducted in collaboration with the Population Research Institute reviewed a total of 24 studies published in peer-reviewed journals and found a significant increased risk of acquiring HIV when using Depo-Provera and other injectables.

DMPA was found to increase women’s risk of contracting HIV by 49% compared to women not using steriodal (hormonal) contraceptives (HR = 1.49, 95% CI 1.28-1.73). Over 88% of cross-sectional studies and over 75% of longitudinal studies observed a positive association between HIV acquisition and DMPA use.

One study found that, in the presence of concentrations of MPA in similar to serum levels of MPA found in women after receiving a DMPA injection, MPA significantly increases transcytosis of HIV across genital epithelial cells in vitro.iv Epithelial layers in the genital tract are crucial preventing the HIV virus from reaching stromal tissues where active infection of target leukocytes such as CD4+ T cells and macrophages is easily effected.

Governments and organizations spend millions every year on DMPA around the world, mostly targeting Africa.

In spite of the evidence indicating an associated risk, government agencies and NGOs continue to provide over $75 million USD per year in DMPA injectables, mostly to Sub-Saharan African countries.


Exposing the dangers of DMPA have been a major effort for the Population Research Institute. Our educational video, “Depo’s Deception: New Dangers for African Women” has reached over 1.1 million views on Facebook alone.


Educate and expose the dangers of DMPA.

Defund organizations that spread the use of DMPA around the world

Legislate against the spread of dangerous injectable contraceptives around the world.

Help expose the dangers of Depo-Provera.
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